Design, synthesis and docking studies of novel dipeptidyl boronic acid proteasome inhibitors constructed from αα- and αβ-amino acids.
作者： Jingmiao Shi , Meng Lei , Wenkui Wu , Huayun Feng , Jia Wang
DOI: 10.1016/J.BMCL.2016.03.007
关键词:
摘要: A series of novel dipeptidyl boronic acid proteasome inhibitors constructed from αα- and αβ-amino acids were designed synthesized. Their structures elucidated by (1)H NMR, (13)C LC-MS HRMS. These compounds evaluated for their β5 subunit inhibitory activities human proteasome. The results showed that composed αα-amino as active bortezomib. Interestingly, the those derived lost completely. Of all inhibitors, compound 22 (IC50=4.82 nM) was most potent inhibition activity. Compound also against three MM cell lines with IC50 values less than 5 nM in inhibiting growth assays. Molecular docking studies displayed fitted very well pocket
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