α-Spinasterol, a TRPV1 receptor antagonist, elevates the seizure threshold in three acute seizure tests in mice.

摘要: α-Spinasterol is a plant-derived compound which was reported to act as selective antagonist for the transient receptor potential vanilloid 1 (TRPV1) receptor. Several studies revealed that TRPV1 receptors might modulate seizure activity in animal models of seizures and epilepsy. The aim present study investigate effect α-spinasterol on threshold three acute seizures, i.e., intravenous (i.v.) pentylenetetrazole (PTZ) test, maximal electroshock (MEST) test model psychomotor induced by 6 Hz stimulation mice. Our results significant anticonvulsant all used tests. In i.v. PTZ statistically elevation noted case myoclonic twitches (doses 0.1–1 mg/kg) generalized clonus 0.5 but not tonic seizures. studied also increased hindlimb extension MEST 0.1 tests Furthermore, did produce any impairment motor coordination (assessed chimney test) muscular strength (investigated grip-strength it provoke changes body temperature Based our fact characterized good blood–brain permeability, we postulate further investigation this precisely evaluate mechanism its action opportunity usage clinical practice.