The assessment of the scale-up performance of the extrusion/spheronisation process

摘要: Abstract The ability to predict the spheronisation performance of a standard extrudate over 125-fold range has been assessed in terms spheroid quality produced. It found possible 25 kg batch on 65.6 cm diameter production spheroniser from experiments (with 22.9 laboratory spheroniser). To achieve such prediction it is necessary use good and operate at rotational speeds which give same linear peripheral velocity plate.