Role of base plate rotational speed in controlling spheroid size distribution and minimizing oversize particle formation during spheroid production by rotary processing.

摘要: The occurrence of material adhesion and formation oversize particles in the product yield during one-pot spheroid production by rotary processing leads to a less predictable process decrease usable portion total obtained from each run. use variable speeds rotating frictional base plate spheronization run was investigated for achieving optimal production. When speed increased liquid addition, greater centrifugal forces generated improved distribution mixing moist powder mass, resulting amount formed. maintained at high throughout run, mean size increased, “between batch” variability also observed. findings showed that, when higher were used, residence time must be adjusted accordingly avoid excessi...