Scale Up and Technology Transfer of Pharmaceutical Suspensions

摘要: Scaling up of suspension dosage form is considered a challenge as pharmaceutical suspensions are thermodynamically unstable. During the scale-up process, effect operational variables on dispersion and physical properties affecting overall attributes need systematic evaluation. Though scale process can be studied using dimensional analysis, mathematical modeling, computer simulation, most work in field manufacturing still depends empirical studies principles geometric similarities. Various aspects technology transfer, analytical (PAT) applications discussed.