Tissue kallikrein protects rat hippocampal CA1 neurons against cerebral ischemia/reperfusion‐induced injury through the B2R‐Raf‐MEK1/2‐ERK1/2 pathway
作者： Zheng Wang , Xiang Han , Mei Cui , Kun Fang , Zhengyu Lu
DOI: 10.1002/JNR.23325
关键词:
摘要: We have documented that tissue kallikrein (TK) prevents neurons from hypoxia/reoxygenation injury through the B2R-ERK1/2 pathway and antihypoxic function of TK Homer1b/c-ERK1/2 signaling pathways. The present study investigates molecular mechanisms exogenous activation β-arrestin-2 assembled B2R-Raf-MEK1/2 module in vivo. cresyl violet staining results indicated protected rat hippocampal CA1 against cerebral ischemia/reperfusion (I/R) injury. immunoprecipitation (IP) immunoblotting (IB) revealed upregulated phosphorylation Raf (p-Raf), MEK1/2 (p-MEK1/2), ERK1/2 (p-ERK1/2). Meanwhile, expression nuclear factor-κB (NF-κB), depressed release cytochrome c (Cyt c) bax mitochondria to cytosol, caspase-3. Take together, our suggest attenuated I/R induced activating activated could upregulate NF-κB, decrease depress © 2014 Wiley Periodicals, Inc.
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