Antiserum against perimicrovillar membranes and midgut tissue reduces the development of Trypanosoma cruzi in the insect vector, Rhodnius prolixus
作者： MS Gonzalez , A Hamedi , JM Albuquerque-Cunha , NFS Nogueira , W De Souza
DOI: 10.1016/J.EXPPARA.2006.04.009
关键词:
摘要: Antiserum raised against Rhodnius prolixus perimicrovillar membranes (PMM) and midgut tissue interfered with the structural organization reduced development of Trypanosoma cruzi in R. insect vector. SDS-PAGE Western blot analyses confirmed specific recognition proteins by antibody. Feeding, mortality, molt, oviposition insects were unaffected feeding antiserum. However, eclosion eggs from females treated Additionally, vivo evaluation showed that after oral treatment antiserum, intensity infection Dm-28c clone T. decreased digestive tract fifth-instar nymphs excretions adults. These results suggest changes observed PMM posterior may not be important for triatomine survival but antiserum acts as a transmission-reduction vaccine able to induce significant decreases
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