Expression of high p53 levels in colorectal cancer: a favourable prognostic factor
作者： E Adrover , M L Maestro , M T Sanz-Casla , V del Barco , J Cerdán
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摘要: The expression of p53 protein was examined in a series 111 colorectal cancer adenocarcinomas with long follow-up. A quantitative luminometric immunoassay (LIA) used for the measurement wild-type and mutant extracts from tumour cytosols, being detected 42% samples (range 0.0–52 ng mg−1). Using an arbitrary cut-off value 2.7 mg−1, 25% tumours were classified as manifesting high levels. There no association patient age, sex, serum preoperative carcinoembryonic antigen (CEA) levels, site size, nodal status or TNM stage. Significant independent correlation found to exist between levels prolonged disease-free survival (P = 0.05) at median follow-up 60 months. This advantage most apparent among stage III patients. results this study would suggest that appear be useful selecting group patients better prognosis. © 1999 Cancer Research Campaign
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sci-hub.se 参考文章(30)
Laura C. Lovato, Dennis J. Ahnen, Paul A. Bunn, Frank L. Meyskens, Polly Feigl, John D. Wells, Grant Stemmerman, Gang Quan, Cecelia Fenoglio-Preiser, John S. Macdonald, Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study. Cancer Research. ,vol. 58, pp. 1149- 1158 ,(1998)
Bert Vogelstein, David Sidransky, Ruth W. Craig, Michael B. Kastan, Onyinye Onyekwere, Participation of p53 Protein in the Cellular Response to DNA Damage Cancer Research. ,vol. 51, pp. 6304- 6311 ,(1991)
J S Lee, A Yoon, S K Kalapurakal, J Y Ro, J J Lee, N Tu, W N Hittelman, W K Hong, Expression of p53 oncoprotein in non-small-cell lung cancer: a favorable prognostic factor. Journal of Clinical Oncology. ,vol. 13, pp. 1893- 1903 ,(1995) , 10.1200/JCO.1995.13.8.1893
Richard M. Elledge, D. Craig Allred, The p53 tumor suppressor gene in breast cancer. Breast Cancer Research and Treatment. ,vol. 32, pp. 39- 47 ,(1994) , 10.1007/BF00666204
J Lennerstrand, M Stenmark-Askmalm, M Fernö, A Brisfors, A Ohrvik, O Stål, D Killander, D Lane, J Brundell, A Borg, Prognostic significance of p53 overexpression in primary breast cancer; a novel luminometric immunoassay applicable on steroid receptor cytosols. British Journal of Cancer. ,vol. 71, pp. 1013- 1017 ,(1995) , 10.1038/BJC.1995.195
David Wynford-Thomas, P53 in tumour pathology: Can we trust immunocytochemistry? The Journal of Pathology. ,vol. 166, pp. 329- 330 ,(1992) , 10.1002/PATH.1711660402
A Yamaguchi, G Nakagawara, Y Kurosaka, G Nishimura, Y Yonemura, I Miyazaki, p53 immunoreaction in endoscopic biopsy specimens of colorectal cancer, and its prognostic significance British Journal of Cancer. ,vol. 68, pp. 399- 402 ,(1993) , 10.1038/BJC.1993.348
Xiao-Feng Sun, John M. Carstensen, Olle Stål, Hong Zhang, Erik Nilsson, Rune Sjödahl, Bo Nordenskjöld, Prognostic significance of p53 expression in relation to DNA ploidy in colorectal adenocarcinoma Virchows Archiv A Pathological Anatomy and Histopathology. ,vol. 423, pp. 443- 448 ,(1993) , 10.1007/BF01606533
David S. Nathanson, Michael D. Linden, Paul Tender, Richard J. Zarbo, Gordon Jacobsen, Lisa T. Nelson, Relationship among p53, stage, and prognosis of large bowel cancer. Diseases of The Colon & Rectum. ,vol. 37, pp. 527- 534 ,(1994) , 10.1007/BF02050985
D Ofner, H Maier, B Riedmann, P Holzberger, M Nogler, M Totsch, A Bankfalvi, G Winde, W Bocker, K W Schmid, Immunohistochemically detectable p53 and mdm-2 oncoprotein expression in colorectal carcinoma: prognostic significance. Clinical molecular pathology. ,vol. 48, ,(1995) , 10.1136/MP.48.1.M12