FOXM1 and FOXQ1 are promising prognostic biomarkers and novel targets of tumor-suppressive miR-342 in human colorectal cancer

摘要: Purpose: Colorectal cancer (CRC) ranks as the third most frequent type, and its incidence continues to rise gradually worldwide, highlighting need identify previously unrecognized molecular events that propel development of this malignancy. Recent evidence suggests dysregulated expression FOX family transcription factors may be critical in various genetic disorders well cancer; however, functional clinical significance pathway CRC remains unclear. Experimental Design Results: Herein, we performed a systematic comprehensive discovery step by evaluating members, identified FOXM1 FOXQ1 are frequently overexpressed CRC. We subsequently confirmed these findings two large testing cohorts (n=550), an independent validation cohort (n=134), which high emerged prognostic factor patients. supported performing assays knockdown resulted inhibited cell proliferation, suppressed migration invasion cells. Furthermore, using bioinformatics approaches, miR-342 novel regulator both FOXQ1. Overexpression or inhibition modulated genes contributed phenotypic alterations cells, was validated xenograft animal model. Conclusions: Collectively, have firstly promising biomarkers patients, provide therapeutic targeting potential treatment approach