Development of mucosal-associated invariant T cells.
作者： Hui-Fern Koay , Dale I Godfrey , Daniel G Pellicci
DOI: 10.1111/IMCB.12039
关键词:
摘要: Mucosal-associated invariant T (MAIT) cells develop in the thymus and migrate into periphery to become largest antigen-specific αβ T-cell population human immune system. However, frequency of MAIT varies widely between individuals, basis for this is unclear. While are highly conserved through evolution phenotypically similar humans mice, they represent a much smaller proportion total mice. In review, we discuss how transition three-stage development pathway both mouse thymus, continue mature expand after leave thymus. Moreover, will explore speculate on specific factors regulate different stages process.
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