The p53 codon 72 polymorphism and risk of high-grade cervical intraepithelial neoplasia

摘要: Abstract Background: The Arg / genotype versus Pro or at codon 72 of the p53 gene has been implicated in increasing susceptibility cervix to human papillomavirus (HPV) infection and thus altering cancer risk. However, research on this topic contentious, which prompted us carry out a case–control study Montreal area. Methods: Cases were women with histologically-confirmed high-grade cervical intraepithelial neoplasia (HGCIN). Controls without history abnormalities. From each woman, we obtained specimen for HPV testing genotyping, questionnaire was completed. DNA sequencing used minimize misclassification. A subsample specimens also genotyped using TaqMan assay. Results: There 357 cases 760 controls recruited between February 2001 December 2003. distribution , 55.2, 36.4 8.4%, respectively, among cases, 52.1, 38.7 9.2%, controls, corresponding an odds ratio (OR) adjusted ancestral origin 1.16 (95% confidence interval (CI): 0.9–1.5) other genotypes. When restricted high-risk HPV-positive women, ORs 1.40 (CI: 0.9–2.1) 2.12 1.1–4.2), genotypes Pro, respectively. findings comparable analyses results that agreed TaqMan. Conclusions: In study, attempted selection bias, population stratification suggest role polymorphism HGCIN is weak best. Further may reveal if stronger influence risk invasive cancer.