Upregulation of miR-181a suppresses the formation of glioblastoma stem cells by targeting the Notch2 oncogene and correlates with good prognosis in patients with glioblastoma multiforme.
作者： Shi-Xiong Huang , Zhong-Yan Zhao , Guo-Hu Weng , Xiang-Ying He , Chan-Ji Wu
DOI: 10.1016/J.BBRC.2017.04.008
关键词:
摘要: Glioblastoma stem-like cells (GSCs) are responsible for the initiation and progression of glioblastoma multiforme (GBM), microRNAs (miRNAs) play an important role in this disease. However, mechanisms underlying miRNAs stemness GSCs have not been completely elucidated. We previously showed that miR-181a is downregulated GBM may predict prognosis patients with Here, we demonstrate upregulation suppressed GSC formation inhibited tumorigenesis by targeting Notch2 oncogene. found was derived from human U87MG U373MG cells. The high expression levels stemness-related markers CD133 BMI1, attenuated sphere proliferation, promoted cell apoptosis, reduced tumorigenicity GSCs. MiR-181a decreased 3'-untranslated region its mRNA. overexpression effects downregulation on GSCs, negatively correlated expression. Moreover, together low a shorter median overall survival patients. Together, these data show essential Notch2, suggesting potential prognostic value as tumor biomarkers
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