c-FOS suppresses ovarian cancer progression by changing adhesion

摘要: C-Fos was initially described as oncogene, but associated with favourable prognosis in ovarian cancer (OvCa) patients. The molecular and functional aspects underlying this effect are still unknown. Using stable transfectants of SKOV3 OVCAR8 cells, proliferation, migration, invasion apoptotic potential c-FOS-overexpressing clones controls were compared. Adherence to components the extracellular matrix analysed static assays, adhesion E-selectin, endothelial mesothelial cells dynamic flow assays. c-FOS vivo studied after intraperitoneal injection into SCID mice, changes gene expression determined by microarray analysis. Tumour growth mice strongly delayed overexpression, reduction lung metastases circulating tumour cells. In vitro, had only weak influence on proliferation pro-apoptotic. Adhesion (collagen I, IV) significantly reduced OvCa This corresponds deregulation proteins glycosylation enzymes addition its known pro-apoptotic effect, might progression changing peritoneal surfaces.