Degradable polyurethane nanoparticles containing vegetable oils

摘要: The development of colloidal delivery systems from degradable polyurethanes (PU) has attracted increasing interest as the highly variable synthetic chemistry PU may be exploited to generate polymers having properties ranging very soft elastomers rigid plastics. In this work, synthesis nanoparticles using isophorone diisocyanate, castor oil, and poly(e‐caprolactone) monomers containing high amounts vegetable oils acai oil crodamol GTCCwas studied. effect surfactants Tween 80 sodium dodecyl sulfate (SDS) poly(ethylene glycol) molar masses 400, 600, 1000g/mol on stability, size, nanoparticle morphology was evaluated. Stable dispersions with sizes between 50–70nm 170–250nm were achieved when, respectively, SDS used surfactant. polyol type in step polymerization miniemulsion had a major mass resulting nanoparticles. more pronounced when Castor employed. Increasing PEG increased average particle size PU. Finally, strong reduction observed degradation assays those maintained during 30 days at 37°C pH 7.0. Practical applications: Using natural renewable obtain polyurethane combined incorporation other therein showed good results terms size. simple straightforward procedure prepare by contributes improve application range these polymers.