SRC-3/AIB1 protein and gene amplification levels in human esophageal squamous cell carcinomas.
作者： Fang-Ping Xu , Dan Xie , Jian-Ming Wen , Hui-Xi Wu , Yong-Dong Liu
DOI: 10.1016/J.CANLET.2005.12.030
关键词:
摘要: It has been suggested that the steroid receptor coactivatior-3 (SRC-3) gene, also known as AIB1, ACTR, RAC3, p/CIP and TRAM-1, located at 20q12, plays an oncogenic role in several types of human cancers. In this study, we examined encoded protein expression SRC-3 its copy number 221 esophageal squamous cell carcinomas (ESCCs). ESCC series, overexpression increased gene was detected 46 13% ESCCs, respectively. addition, observed more frequently primary ESCCs late T stages (T3/T4) than earlier T1/T2 (P 0.05). These results suggest SRC-3, caused by amplification/gain or other molecular mechanisms, might provide a selective advantage for development local invasion certain subsets ESCC. significant correlation (P<0.05) with proliferation (through detection Ki-67 expression) these ESCCs. findings potential control proliferation; such may be responsible, least part, tumorigenesis and/or progression
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