Comparison of skin barrier function and sensory nerve electric current perception threshold between IgE-high extrinsic and IgE-normal intrinsic types of atopic dermatitis

摘要: Background Two types of atopic dermatitis (AD) have been proposed, with different pathophysiological mechanisms underlying this seemingly heterogeneous disorder. The extrinsic type shows high IgE levels presumably as a consequence skin barrier damage and feasible allergen permeation, whereas the intrinsic exhibits normal is not mediated by allergen-specific IgE. Objectives To investigate relationship between pruritus perception threshold function patients AD in comparison types. Methods Enrolled study were 32 AD, 17 24 healthy individuals. stratum corneum was assessed surface hydration transepidermal water loss (TEWL), evaluated electric current (CPT) sensory nerves upon neuroselective transcutaneous stimulation. Results Skin significantly lower TEWL higher than or controls. Although there no statistically significant difference CPT among controls, correlated inversely but AD. Finally, visual analogue scale itch nonlesional Conclusions Patients an impaired barrier, which increases pre-existing rather decreases sensitivity to external stimuli. In contrast, retain reactivity pruritic