Release of Leukotriene A4 Versus Leukotriene B4 from Human Polymorphonuclear Leukocytes
作者： Angelo Sala , Manlio Bolla , Simona Zarini , Reiner Müller-Peddinghaus , Giancarlo Folco
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摘要: The reactive intermediate formed by 5-lipoxygenase metabolism of arachidonic acid, leukotriene A4, is known to be released from cells and subsequently taken up other for biochemical processing. objective this study was determine the relative amount A4 synthesized human polymorphonuclear leukocytes (PMNL) that available transcellular biosynthetic processes. This accomplished diluting cell suspensions measuring amounts enzymatic versus nonenzymatic A4-derived metabolites after challenge with Ca2+ ionophore A23187. Nonenzymatic were used as a quantitative index into extracellular milieu. results obtained demonstrated in PMNL, increased decreasing concentrations. After 20-fold dilution PMNL preparations, doubling observed following (from 53.9 ± 1.3 110.4 8.9 pmol/106 p
sci-hub.se 参考文章(34)
PIERRE BORGEAT, MARIE NADEAU, HASSAN SALARI, PATRICE POUBELLE, BERNARD FRUTEAU DE LACLOS, Leukotrienes: biosynthesis, metabolism, and analysis. Advances in lipid research. ,vol. 21, pp. 47- 77 ,(1985) , 10.1016/B978-0-12-024921-3.50008-3
F A Fitzpatrick, D R Morton, M A Wynalda, Albumin stabilizes leukotriene A4. Journal of Biological Chemistry. ,vol. 257, pp. 4680- 4683 ,(1982) , 10.1016/S0021-9258(18)34575-7
S J Feinmark, P J Cannon, Endothelial cell leukotriene C4 synthesis results from intercellular transfer of leukotriene A4 synthesized by polymorphonuclear leukocytes. Journal of Biological Chemistry. ,vol. 261, pp. 16466- 16472 ,(1986) , 10.1016/S0021-9258(18)66589-5
P. Borgeat, B. Samuelsson, Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds. Journal of Biological Chemistry. ,vol. 254, pp. 7865- 7869 ,(1979) , 10.1016/S0021-9258(18)36026-5
F Grimminger, W Seeger, G Becker, U Schneider, B Kreusler, Influence of microvascular adherence on neutrophil leukotriene generation. Evidence for cooperative eicosanoid synthesis. Journal of Immunology. ,vol. 144, pp. 1866- 1872 ,(1990)
J A Maclouf, R C Murphy, Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential cellular source of leukotriene C4. Journal of Biological Chemistry. ,vol. 263, pp. 174- 181 ,(1988) , 10.1016/S0021-9258(19)57375-6
S Shak, I M Goldstein, Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes. Journal of Biological Chemistry. ,vol. 259, pp. 10181- 10187 ,(1984) , 10.1016/S0021-9258(18)90946-4
B J Undem, F H Chilton, M Cluzel, Release of platelet-activating factor and the metabolism of leukotriene B4 by the human neutrophil when studied in a cell superfusion model. Journal of Immunology. ,vol. 143, pp. 3659- 3665 ,(1989)
T. M. McIntyre, G. A. Zimmerman, S. M. Prescott, Leukotrienes C4 and D4 stimulate human endothelial cells to synthesize platelet-activating factor and bind neutrophils. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 2204- 2208 ,(1986) , 10.1073/PNAS.83.7.2204
S. E. Dahlen, J. Bjork, P. Hedqvist, K. E. Arfors, S. Hammarstrom, J. A. Lindgren, B. Samuelsson, Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response Proceedings of the National Academy of Sciences of the United States of America. ,vol. 78, pp. 3887- 3891 ,(1981) , 10.1073/PNAS.78.6.3887