Computational simulation of carotid stenosis and flow dynamics based on patient ultrasound data – A new tool for risk assessment and surgical planning

摘要: Abstract Purpose There is nowadays extensive experimental and computational investigation on the pathophysiology of atherosclerosis, searching correlations between its focal nature local hemodynamic environment. The goal this work to present a methodology for patient-specific hemodynamics study carotid artery bifurcation based use ultrasound (US) morphological blood flow velocity patient data. Materials/methods Subject-specific studies were performed two patients, using developed finite element code. Geometrical models obtained from acquisition longitudinal sequential cross-sectional images boundary conditions Doppler measurements at common artery. Results was good agreement imaging data simulated results. For normal stenosed velocity, wall shear stress (WSS) WSS descriptors analysis illustrated extremely complex behavior along cardiac cycle. Different patterns found, associated with morphology conditions. High values time-averaged (TAWSS) found stenosis site both patients TAWSS fields presented low within areas high oscillating index relative residence time values, corresponding recirculation zones. Conclusion Simulated parameters able capture disturbed in bifurcation, which play an important role development atherosclerotic plaques. Computational simulations clinic US might help improving diagnostic treatment management atherosclerosis.