Deterioration of trabecular plate-rod and cortical microarchitecture and reduced bone stiffness at distal radius and tibia in postmenopausal women with vertebral fractures.

摘要: Postmenopausal women with vertebral fractures have abnormal bone microarchitecture at the distal radius and tibia by HR-pQCT, independent of areal BMD. However, whether trabecular plate rod is altered in unknown. This study aims to characterize abnormalities microarchitecture, cortex, stiffness postmenopausal fractures. HR-pQCT images were acquired from 45 control subjects without Trabecular cortical compartments separated an automatic segmentation algorithm subjected individual trabecula (ITS) analysis for measuring morphology evaluation thickness porosity, respectively. Whole estimated finite element analysis. Fracture did not differ according age, race, body mass index, osteoporosis risk factors, or medication use. Women had thinner cortices, larger area compared group. By ITS analysis, fracture fewer plates, less axially aligned trabeculae connectivity both tibia. Fewer rods observed radius. 18% 22% lower radius, 19% 16% tibia, controls. The failure load also reduced 13% 14%, In summary, microstructural deterioration peripheral skeleton, a preferential loss plates thinning. These deficits translated into whole Our results suggest that microstructure may be important mechanisms women.