Eph receptor and ephrin ligand-mediated interactions during angiogenesis and tumor progression.

摘要: Eph receptors comprise the largest family of receptor tyrosine kinases. They are classified into an A and a B on basis characteristic properties corresponding ephrin ligands which either GPI-anchored peripheral membrane molecules (A class ephrins) or transmembrane (B ephrins). were originally identified as neuronal pathfinding molecules. Yet, gene targeting experiments in mice have EphB/ephrinB system critical rate-limiting determinant arterio-venous differentiation during embryonic vascular development. Identification functions has last few years stimulated two emerging fields biology research, namely (1) molecular analysis structural functional mechanisms differentiation, (2) study commonalities between guidance patterning mechanisms. This review summarizes current understanding ligand provides overview roles Eph/ephrin controlling tumor tumorigenesis progression.