Targeting the ERK signaling pathway in cancer therapy
作者： Michiaki Kohno , Jacques Pouyssegur
DOI: 10.1080/07853890600551037
关键词:
摘要: The extracellular signal-regulated kinase (ERK) signaling pathway is a major determinant in the control of diverse cellular processes such as proliferation, survival, differentiation and motility. This often up-regulated human tumors represents an attractive target for development anticancer drugs. Because its multiple roles acquisition complex malignant phenotype, specific blockade ERK expected to result not only anti-proliferative effect but also anti-metastatic anti-angiogenic effects tumor cells. Recently potent small-molecule inhibitors targeting components have been developed. Among them, BAY 43-9006 (Raf inhibitor), PD184352, PD0325901 ARRY-142886 (MEK1/2 inhibitors) reached clinical trial stage. We briefly discuss possibility that combination (cytostatic agents) conventional drugs (cytotoxic provides excellent basis new chemotherapeutic strategies against cancer.
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