Molecular Pathogenesis of Urothelial Carcinoma and the Development of Novel Therapeutic Strategies

摘要: The elucidation of the molecular pathogenesis urothelial cancers (UC) has helped classify these tumors and identify candidate biomarkers therapeutic targets. Superficial non-aggressive are characterized by expression mutationally activated growth factor signaling molecules whereas loss tumor suppressor genes is a typical feature higher grade more invasive tumors. Thus, assays to detect genetic anomalies or associated phenotypic markers assist in diagnosis management early stage disease. For advanced diseases, development agents that interrupt aberrant signals other biochemical effects induced specific mutations may lead novel effective medical therapies.