Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinoma
作者： Martin G. Friedrich , Shahin Chandrasoma , Kimberly D. Siegmund , Daniel J. Weisenberger , Jonathan C. Cheng
DOI: 10.1016/J.EJCA.2005.07.019
关键词:
摘要: Abstract There is increasing evidence for the role of epigenetic gene silencing in superficial bladder cancer. The aim current study was to investigate prognostic value alterations patients with non-muscle invasive carcinoma. We checked methylation status 20 cancer associated genes ( p14ARF , p16 CDKN2A STAT-1 SOCS-1 DR-3 DR-6 PIG-7 BCL-2 H-TERT BAX EDNRB DAPK RASSF-1A FADD TMS-1 E-Cadherin ICAM-1 TIMP-3 MLH-1 COX-2 ) DNA methylation. analysed microdissected tumour samples from 105 consecutive primary Quantitative analysis CpG sites promoter region performed sensitive quantitative real time PCR (‘Methylight'). Univariate association recurrence carried out Kaplan–Meier and log-rank test. Follow-up data were available 95/105 (91.4%). A observed 26 (27.3%). could identify six ), where recurrence. In analysis, showed a significant free survival. Methylation predicted prolonged disease interval. this study, we report comprehensive on relevance identified one more favourable outcome. Our strongly support usefulness as marker
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