E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer.
作者： Martin Oeggerli , Sanja Tomovska , Peter Schraml , Daniele Calvano-Forte , Salome Schafroth
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摘要: E2F3 is located in the 6p22 bladder amplicon and encodes a transcription factor important for cell cycle regulation DNA replication. To further investigate role of cancer, tissue microarray containing samples from 2317 tumors was used gene copy number expression analysis by means fluorescence situ hybridization (FISH) immunohistochemistry (IHC). amplification strongly associated with invasive tumor phenotype high grade (P<0.0001 each). None 272 pTaG1/G2 tumors, but 35 311 pT1-4 carcinomas (11.3%), had amplification. A level grade, advanced stage, evaluate whether correlates proliferation, Ki67 labeling index (LI) analysed each tumor. There strong association between LI (P<0.0001), which independent stage. We conclude that frequently amplified overexpressed invasively growing cancer (stage pT1-4). appears to provide growth advantage cells activating proliferation subset tumors.
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