Original Articles: Bladder Cancer: Long-Term Outcome Related to Epidermal Growth Factor Receptor Status in Bladder Cancer

作者: Kilian Mellon , Chris Wright , Peter Kelly , C.H. Wilson Horne , David E. Neal

DOI: 10.1016/S0022-5347(01)67604-3

关键词: Clinical significancePathologyInternal medicineOncologyEpitheliomaCarcinomaUrinary bladderImmunohistochemistryEpidermal growth factor receptorEpidermal growth factorMedicineBladder cancer

摘要: ABSTRACTFor bladder cancer we currently lack accurate methods of predicting outcome, although clinical stage and histological grade are broad determinants prognosis. Preliminary data have indicated that assessment epidermal growth factor receptor status is a method further subclassifying cancer. We assessed prospectively the significance determining in 212 patients with newly diagnosed who were followed for 1 to 96 months (mean 26.5). In multivariate analyses was confirmed be an independent predictor survival (p = 0.004) progression 0.0004). Most importantly, found 80% sensitive 93% specific T1, 3 conclude useful molecular marker cancer, especially those without infiltration de...

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