HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

作者: Caroline G. L. Lee , Michael M. Gottesman , Carol O. Cardarelli , Muralidhara Ramachandra , Kuan-Teh Jeang

DOI: 10.1021/BI972709X

关键词:

摘要: … For studies with Bodipy analogues, approximately 1 × 10 5 of either NIH3T3 or NIH-MDR-… Vinblastine sensitivity of parental KB-3-1 and multidrug-resistant KB-V1 were evaluated by …

参考文章(12)
C.O. Cardarelli, I Pastan, M.M. Gottesman, S.J. Currier, S.E. Kane, M.C. Willingham, Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters. Journal of Biological Chemistry. ,vol. 267, pp. 25153- 25159 ,(1992) , 10.1016/S0021-9258(19)74018-6
L M Greenberger, C P Yang, E Gindin, S B Horwitz, Photoaffinity probes for the alpha 1-adrenergic receptor and the calcium channel bind to a common domain in P-glycoprotein. Journal of Biological Chemistry. ,vol. 265, pp. 4394- 4401 ,(1990) , 10.1016/S0021-9258(19)39578-X
Jean E. Merrill, Irvin S. Y. Chen, HIV‐1, macrophages, glial cells, and cytokines in AIDS nervous system disease The FASEB Journal. ,vol. 5, pp. 2391- 2397 ,(1991) , 10.1096/FASEBJ.5.10.2065887
Monte S. Meltzer, Donald R. Skillman, Peter J. Gomatos, D. Chester Kalter, Howard E. Gendelman, Role of Mononuclear Phagocytes in the Pathogenesis of Human Immunodeficiency Virus Infection Annual Review of Immunology. ,vol. 8, pp. 169- 194 ,(1990) , 10.1146/ANNUREV.IY.08.040190.001125
C Cordon-Cardo, J P O'Brien, J Boccia, D Casals, J R Bertino, M R Melamed, Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. Journal of Histochemistry and Cytochemistry. ,vol. 38, pp. 1277- 1287 ,(1990) , 10.1177/38.9.1974900
Édith BEAULIEU, Michel DEMEULE, Lucian GHITESCU, Richard BÉLIVEAU, P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain. Biochemical Journal. ,vol. 326, pp. 539- 544 ,(1997) , 10.1042/BJ3260539
Agnès D. Didier, Francis Loor, Decreased biotolerability for ivermectin and cyclosporin a in mice exposed to potent P-glycoprotein inhibitors International Journal of Cancer. ,vol. 63, pp. 263- 267 ,(1995) , 10.1002/IJC.2910630220
Michael M. Gottesman, Ira Pastan, Biochemistry of Multidrug Resistance Mediated by the Multidrug Transporter Annual Review of Biochemistry. ,vol. 62, pp. 385- 427 ,(1993) , 10.1146/ANNUREV.BI.62.070193.002125
Ursula Bommhardt, Jean-Charles Cerottini, H. Robson MacDonald, Heterogeneity in P-glycoprotein (multidrug resistance) activity among murine peripheral T cells: correlation with surface phenotype and effector function. European Journal of Immunology. ,vol. 24, pp. 2974- 2981 ,(1994) , 10.1002/EJI.1830241208