Receptors for complement and immunoglobulin on human leukemic cells and human lymphoblastoid cell lines
作者： Ethan M. Shevach , Ronald Herberman , Michael M. Frank , Ira Green
DOI: 10.1172/JCI106999
关键词:
摘要: The bone marrow-derived (B) lymphocyte can be identified by the presence of easily detectable surface immunoglobulin and a receptor for antigen-antibody-complement complexes (EAC'). Monocytes macrophages also bear EAC' in addition possess red cell-IgG (EA). Thymus-derived (T) lymphocytes neither these receptors. cells 15 patients with leukemia 19 human lymphoblastoid cell lines were examined EA Of leukemias studied, only from chronic lymphatic (CLL) receptor. could not demonstrated on CLL cells; hence, this criteria represent B lymphocytes. 12/19 studied classified as absence 2/19 possessed both receptors thus resemble monocyte. 5/19 had no or EA. approach presented study classification to their lymphocyte, T monocyte origin may have useful diagnostic therapeutic implications.
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