Effects of aging on the common lymphoid progenitor to pro-B cell transition.

摘要: The number of common lymphoid progenitors (CLP) and their pre-pro-B pro-B cell progeny is reduced in old mice, but the age-related changes responsible for these declines have not been fully elucidated. aim this study was to provide additional insights into impact senescence on early B development by analyzing CLP compartments under steady-state conditions after cytoablation with 5-fluorouracil. 5-Fluorouracil subjects hemopoietic system acute stress has advantage revealing defects that may otherwise be subtle. data demonstrate significant, proliferative potential precursors suggest ability differentiate cells also compromised senescence. These lymphopoiesis do result from a general defect HSC or bone marrow microenvironment impairs all lineages. Instead, demonstrating myeloid progenitor developmental decline age indicate particularly sensitive accumulate during