5-methyltetrahydrofolic acid is not a methyl donor for biogenic amines: enzymatic formation of formaldehyde.

作者: E Meller , H Rosengarten , A. Friedhoff , R. Stebbins , R Silber

DOI: 10.1126/SCIENCE.1111095

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摘要: Contrary to previous reports, 5-methyltetrahydrofolic acid does not mediate the methylation of dopamine epinine. Instead, this methyl donor is degraded enzymatically formaldehyde, which condenses with form a tetahydoisoquinoline derivative. The latter has chromotographic characteristics very similar those epinine, likely accounts for original misidentification product.

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