Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity.

作者: Kristin J Hope , Liqing Jin , John E Dick

DOI: 10.1038/NI1080

关键词:

摘要: … or LSCs are homogeneous or functionally heterogeneous. Theoretically, all … LSC pool in AML is composed of distinct LSCs that are hierarchically organized because of heterogeneity …

参考文章(39)
A. Blair, D.E. Hogge, L.E. Ailles, P.M. Lansdorp, H.J. Sutherland, Lack of Expression of Thy-1 (CD90) on Acute Myeloid Leukemia Cells With Long-Term Proliferative Ability In Vitro and In Vivo Blood. ,vol. 89, pp. 3104- 3112 ,(1997) , 10.1182/BLOOD.V89.9.3104
G. Güenechea, J.C. Segovia, B. Albella, M. Lamana, M. Ramı́rez, C. Regidor, M.N. Fernández, J.A. Bueren, Delayed Engraftment of Nonobese Diabetic/Severe Combined Immunodeficient Mice Transplanted With Ex Vivo–Expanded Human CD34+ Cord Blood Cells Blood. ,vol. 93, pp. 1097- 1105 ,(1999) , 10.1182/BLOOD.V93.3.1097
Guillermo Guenechea, Olga I. Gan, Craig Dorrell, John E. Dick, Distinct classes of human stem cells that differ in proliferative and self-renewal potential. Nature Immunology. ,vol. 2, pp. 75- 82 ,(2001) , 10.1038/83199
René Bernards, Robert A. Weinberg, A progression puzzle. Nature. ,vol. 418, pp. 823- 823 ,(2002) , 10.1038/418823A
J. Marx, Mutant Stem Cells May Seed Cancer Science. ,vol. 301, pp. 1308- 1310 ,(2003) , 10.1126/SCIENCE.301.5638.1308
Antonia Follenzi, Laurie E. Ailles, Silvia Bakovic, Massimo Geuna, Luigi Naldini, Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences. Nature Genetics. ,vol. 25, pp. 217- 222 ,(2000) , 10.1038/76095
T Lapidot, F Pflumio, M Doedens, B Murdoch, D. Williams, J. Dick, Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice Science. ,vol. 255, pp. 1137- 1141 ,(1992) , 10.1126/SCIENCE.1372131
M. Greaves, Differentiation-linked leukemogenesis in lymphocytes Science. ,vol. 234, pp. 697- 704 ,(1986) , 10.1126/SCIENCE.3535067