Apoptosis and impaired axonal regeneration of sensory neurons after nerve crush in diabetic rats.
作者： Shuro Kogawa , Hitoshi Yasuda , Masahiko Terada , Kengo Maeda , Ryuichi Kikkawa
DOI: 10.1097/00001756-200003200-00003
关键词:
摘要: We investigated the possible induction of apoptosis dorsal root ganglion (DRG) neurons and defect nerve regeneration after crush injury with reference to JNK/c-jun cAMP pathway in streptozocin-induced diabetic rats. In addition, effects a PGE1 analogue were tested At day 0 (before axonal injury), no TUNEL-positive DRG observed any group. From 1 7 injury, seen rats, but not non-diabetic or PGE1-treated The distance at was shorter rats than other groups time course phosphorylation did parallel apoptosis. 7, content higher that whereas it increased days These results indicate is induced by independently rescues from improves
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