Identification of ING4 (inhibitor of growth 4) as a modulator of docetaxel sensitivity in human lung adenocarcinoma
作者： Rui Wang , Jiayuan Huang , Bing Feng , Wei De , Longbang Chen
DOI: 10.2119/MOLMED.2011.00230
关键词:
摘要: Resistance to docetaxel (DTX) usually occurs in patients with lung adenocarcinoma. To better elucidate the underlying molecular mechanisms involved resistance DTX-based chemotherapy, we established a DTX-resistant adenocarcinoma cell line (SPC-A1/DTX). By gene array analysis, expression of ING4 was found be significantly downregulated SPC-A1/DTX cells. Additionally, decreased induced upon DTX treatment SPC-A1 Overexpression reverses or paclitaxel cells (SPC-A1/DTX A549/Taxol) by inducing apoptosis enhancement and G2/M arrest, small interfering RNA-mediated knockdown renders DTX-sensitive more resistant paclitaxel. Also, overexpression could enhance vivo sensitivity DTX. The phenotypical changes might associated ratio Bcl-2/Bax, which resulted activation caspase-3. level tumors nonresponding lower than that those responders, suggesting positively correlated tumor response Our results provide first evidence essential for Thus, will potential target overcoming chemotherapies
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Masafumi Kumano, Hideaki Miyake, Tomoaki Terakawa, Junya Furukawa, Masato Fujisawa, Suppressed tumour growth and enhanced chemosensitivity by RNA interference targeting Aurora-A in the PC3 human prostate cancer model. BJUI. ,vol. 106, pp. 121- 127 ,(2009) , 10.1111/J.1464-410X.2009.09047.X
Takahiko Oyama, Yoshiyuki Abe, Masafumi Kawamura, Tomohiro Abiko, Koichi Kobayashi, Hitoshi Yamazaki, Masatoshi Gika, Yuriko Saitoh, Masato Nakamura, Yoshimasa Inoue, Bcl-2 overexpression enhances in vitro sensitivity against docetaxel in non-small cell lung cancer. Oncology Reports. ,vol. 13, pp. 259- 264 ,(2005) , 10.3892/OR.13.2.259
Wang Rui, Zhang You-Wei, Chen Long-Bang, Aberrant promoter methylation of FBLN-3 gene and clinicopathological significance in non-small cell lung carcinoma Lung Cancer. ,vol. 69, pp. 239- 244 ,(2010) , 10.1016/J.LUNGCAN.2009.10.009
Limin Cai, Xiaomei Li, Shuyun Zheng, Yanhua Wang, Yandong Wang, Haiyan Li, Jing Yang, Jianfang Sun, Inhibitor of growth 4 is involved in melanomagenesis and induces growth suppression and apoptosis in melanoma cell line M14 Melanoma Research. ,vol. 19, pp. 1- 7 ,(2009) , 10.1097/CMR.0B013E32831BC42F
R.D Baird, S.B Kaye, Drug resistance reversal—are we getting closer? European Journal of Cancer. ,vol. 39, pp. 2450- 2461 ,(2003) , 10.1016/S0959-8049(03)00619-1
David R. Parkinson, Susan G. Arbuck, Timothy Moore, James M. Pluda, Michaele C. Christian, Clinical development of anticancer agents from natural products Stem Cells. ,vol. 12, pp. 30- 43 ,(1994) , 10.1002/STEM.5530120108
Pascal Seve, Charles Dumontet, Chemoresistance in Non-Small Cell Lung Cancer Current Medicinal Chemistry-Anti-Cancer Agents. ,vol. 5, pp. 73- 88 ,(2005) , 10.2174/1568011053352604
Haijuan Wang, Haili Qian, Jian Yu, Xueyan Zhang, Lin Zhang, Ming Fu, Xiao Liang, Qimin Zhan, Chen Lin, Administration of PUMA adenovirus increases the sensitivity of esophageal cancer cells to anticancer drugs. Cancer Biology & Therapy. ,vol. 5, pp. 380- 385 ,(2006) , 10.4161/CBT.5.4.2477
Koji Harada, Supriatno, Yuichiro Kawashima, Yasutaka Itashiki, Hideo Yoshida, Mitsunobu Sato, Down-regulation of S-phase kinase associated protein 2 (Skp2) induces apoptosis in oral cancer cells. Oral Oncology. ,vol. 41, pp. 623- 630 ,(2005) , 10.1016/J.ORALONCOLOGY.2005.02.007
J-P. Sculier, D. Moro-Sibilot, First- and second-line therapy for advanced nonsmall cell lung cancer European Respiratory Journal. ,vol. 33, pp. 915- 930 ,(2009) , 10.1183/09031936.00132008