Drug resistance reversal—are we getting closer?

摘要: Clinical drug resistance is a major barrier to overcome before chemotherapy can become curative for most patients presenting with metastatic cancer. Rational attempts tackle clinical need be based on an understanding of the mechanisms involved; these are likely complex and multifactorial, may due inadequate exposure or alterations in cancer cell itself. This article reviews number strategies used resistance, focussing work our institution related treatment ovarian platinum taxane-based chemotherapy. Further progress towards reversal will require three-pronged approach, namely: development novel cytotoxics which exploit selectively expressed targets; modulation conventional agents and, importantly, serious attempt understand tumour samples taken both pre- post-chemotherapy.