Serum growth hormone-binding protein in obesity: effect of a short-term, very low calorie diet and diet-induced weight loss.
作者： MH Rasmussen , KK Ho , L Kjems , Jannik Hilsted , None
DOI: 10.1210/JCEM.81.4.8636361
关键词:
摘要: GH-binding protein (GHBP) is increased in obesity. It not known whether the increase GHBP reversible with weight loss or modulated by acute changes nutritional intake. To address these questions, we measured 18 obese subjects [body mass index (BMI), 40.9 +/- 1.1 kg/m2 (mean +/-SEM)] before and after an average of 30.3 4.6 kg age- sex matched normal (BMI, 23.0 0.4 kg/m2) studied effects a very low calorie diet over 4 days 5 subgroup (n = 6) 5) loss. was elevated compared to levels sex-matched controls (1.48 0.1 vs. 0.53 nmol/L; P < 0.0001). positively correlated BMI waist circumference (r 0.71; 0.00001 r 0.73; 0.00001, respectively). In addition, insulin as well proinsulin 0.60; 0.001 0.55; 0.001, respectively)...
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