In vitro susceptibility of Candida albicans clinical isolates to eight antifungal agents in Ouagadougou (Burkina Faso).

摘要: Summary Introduction In recent years, the infection Candida albicans worldwide has risen, and incidence of resistance to traditional antifungal therapies is also increasing. The aim this study was evaluate in vitro susceptibility C. albicans clinical isolates eight agents Ouagadougou. Materials methods A cross-sectional conducted from January 2013 December 2015 at Yalgado Ouedraogo University Teaching Hospital. Two hundred seven strains have been isolated 347 symptomatic patients received different services. Samples were cultured on Sabouraud Dextrose Agar supplemented with Cloramphenicol. Isolates diagnosed as using germ tube test, chlamydospore formation Corn Meal Agar, Api-Candida test (Biomerieux). Antifungal testing performed by disk diffusion method classified susceptible, susceptible dose-dependent resistant. Results Three forty-seven (347) are included study. six (206) out collected samples (59.36%) found positive for C. albicans. mostly vulvovaginal (49%) oral infections (40.3%). highest rates azoles obtained fluconazole (66.5%), itraconazole (52.3%) ketoconazole (22.9%) when all included. fluconazole, remain isolates. rate polyene amphotericin B 32.0% 56.4% strains. Resistance nystatin 6.3% Cross-resistance analysis data revealed that fluconazole-resistant significantly higher than recorded fluconazole-susceptible Conclusion showed relatively high commonly widely used (fluconazole, ketoconazole). Most nystatin.