Regulation of MLH1 mRNA and protein expression by promoter methylation in primary colorectal cancer: a descriptive and prognostic cancer marker study
作者： Lars Henrik Jensen , Anders Aamann Rasmussen , Lene Byriel , Hidekazu Kuramochi , Dorthe Gylling Crüger
DOI: 10.1007/S13402-013-0148-2
关键词:
摘要: Background In colorectal cancer MLH1 deficiency causes microsatellite instability, which is relevant for the patient’s prognosis and treatment, its putative heredity. Dysfunction of caused by sporadic gene promoter hypermethylation or hereditary mutations as seen in Lynch Syndrome. The aim this study was to determine detail how DNA methylation regulates expression impacts clinical management.
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