Controlled Systemic Release of Therapeutic Peptides from PEGylated Prodrugs by Serum Proteases
作者： Friederike Inga Nollmann , Tina Goldbach , Nicole Berthold , Ralf Hoffmann
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摘要: A novel concept to release peptidic drugs systemically by serum proteases from a PEGylated precursor makes it possible tune kinetics fit the medical needs. Drug depends on size of PEG polymer and sequence length peptide linker. The antimicrobial activities prodrugs were even better than those free peptides, whereas direct PEGylation abolished activity.
sci-hub.se 参考文章(14)
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