Efficient determination of the pKa values of six chlorinated phenols by reversed-phase liquid chromatography
作者： P. Chaminade , A. Baillet , D. Ferrier , B. Bourguignon , D.L. Massart
DOI: 10.1016/0003-2670(93)80246-H
关键词:
摘要: Abstract A non-linear regression algorithm is used to compute acidity constants from capacity factors recorded at various pH values using a standard reversed-phase column and acetonitrile as organic modifier. An application presented for six chlorophenols the pKa calculated those compounds compare favourable with literature data obtained by other methods in aqueous media. This determination method also suitable mobile phase optimization; resolution map based on liquid chromatography-related presented.
elsevier.com
sci-hub.se 参考文章(10)
Csaba. Horvath, Wayne. Melander, Imre. Molnar, Liquid chromatography of ionogenic substances with nonpolar stationary phases Analytical Chemistry. ,vol. 49, pp. 142- 154 ,(1977) , 10.1021/AC50009A044
Peter J. Shoenmakers, Hugo A.H. Billiet, Leo De Galan, Influence of organic modifiers on the rentention behaviour in reversed-phase liquid chromatography and its consequences for gradient elution Journal of Chromatography A. ,vol. 185, pp. 179- 195 ,(1979) , 10.1016/S0021-9673(00)85604-6
A. C. J. H. Drouen, H. A. H. Billiet, P. J. Schoenmakers, L. de Galan, An improved optimization procedure for the selection of mixed mobile phases in reversed phase liquid chromatography Chromatographia. ,vol. 16, pp. 48- 52 ,(1982) , 10.1007/BF02258868
J. Drahoňovský, Z. Vacek, Dissoziationskonstanten und Austauscherchromatographie chlorierter Phenole Collection of Czechoslovak Chemical Communications. ,vol. 36, pp. 3431- 3440 ,(1971) , 10.1135/CCCC19713431
Joe P. Foley, Willie E. May, Optimization of Secondary Chemical Equilibria in Liquid Chromatography: Theory and Verification Analytical Chemistry. ,vol. 59, pp. 102- 109 ,(1987) , 10.1021/AC00128A022
S. Li, M. Paleologou, W. C. Purdy, Determination of the acidity constants of chlorinated phenolic compounds by liquid chromatography Journal of Chromatographic Science. ,vol. 29, pp. 66- 69 ,(1991) , 10.1093/CHROMSCI/29.2.66
Peter J. Schoenmakers, Optimization of chromatographic selectivity ,(1986)
A. Fischer, G. J. Leary, R. D. Topsom, J. Vaughan, Ionic dissociation of 4-substituted 2,6-dichlorophenols Journal of the Chemical Society B: Physical Organic. pp. 686- 687 ,(1967) , 10.1039/J29670000686
P. D. Bolton, J. Ellis, F. M. Hall, Additive substituent effects on the thermodynamic functions of proton ionization processes. Part III. Phenols with adjacent methyl and chloro-substituents Journal of the Chemical Society B: Physical Organic. pp. 1252- 1255 ,(1970) , 10.1039/J29700001252
Karin Ugland, Elsa Lundanes, Tyge Greibrokk, Alf Bjørseth, Determination of chlorinated phenols by high-performance liquid chromatography Journal of Chromatography A. ,vol. 213, pp. 83- 90 ,(1981) , 10.1016/S0021-9673(00)80635-4