Identification and Management of Paroxysmal Sympathetic Hyperactivity After Traumatic Brain Injury.

摘要: Paroxysmal sympathetic hyperactivity (PSH) has predominantly been described after traumatic brain injury (TBI), which is associated with hyperthermia, hypertension, tachycardia, tachypnea, diaphoresis, dystonia (hypertonia or spasticity), and even motor features such as extensor/flexion posturing. Despite the pathophysiology of PSH not being completely understood, most researchers gradually agree that driven by loss inhibition excitation in nervous system without parasympathetic involvement. Recently, advances clinical diagnostic TBI patients have reached a broad consensus many neurology departments. These should provide more unanimous foundation for systematic research on this syndrome its clear management. Clinically, great deal attention paid to definition criteria, epidemiology pathophysiology, symptomatic treatment, prevention control secondary patients. Potential benefits treatment may result from three main goals: eliminating predisposing causes, mitigating excessive outflow, supportive therapy. However, individual pathophysiological differences, therapeutic responses outcomes, precision medicine approaches management are varied inconsistent between studies. Further, potential drugs might suppress manifestations process treatment. The purpose review present current comprehensive studies identification early stage framework PSH.