c-crbB2 gene amplification and protein expression in ovarian epithelial tumors: Evaluation of their respective prognostic significance by multivariate analysis

摘要: c-erbB2 gene amplification or over-expression has been reported in ovarian cancer, but their prognostic value remains conflicting. To investigate the respective significance of and protein over-expression, tumor samples were obtained from 65 patients with adenocarcinoma (9 FIGO stage I, 7 ll, 38 III 11 IV) followed up for a median period 71 months. (>2.5 a.u.) was detected 9/65 (14%) adenocarcinomas none 5 benign 8 borderline epithelial tumors also analyzed. Specimens 52 available immunohistochemi-cal analysis. expression observed 23/52 (44%) adenocarcinomas. No correlation found between copy number expression. There no any clinico-pathological factors analyzed (i.e., GIGO stage, histological type, grade residual tumor). On univariate analysis, associated poorer survival (p = 0.04). However, multivariate analysis number, did not retain independent 0.19). significant difference without analyses. Therefore, neither nor appears to be marker carcinoma. © 1995 Wiley-Liss, Inc.