The insulin-like growth factors and the lung.
作者： Alan D. Stiles , A. Joseph D'Ercole
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摘要: The insulin-like growth factors (IGF-I and IGF-II) are peptides of about 7,500 D with structural homology to proinsulin that capable stimulating cellular proliferation inducing differentiation. They each encoded by single, large, complex genes direct the transcription multiple mRNAs. Both expressed in most organs tissues, predominantly cells mesenchymal origin. Developmental important their regulation, IGF-II's expression predominating prenatally IGF-I's postnatally. In fetus, placental lactogen can stimulate synthesis both IGF-I IGF-II. After birth, however, hormone nutritional status major regulators IGF-I. addition, a variety other exert tissue-specific stimulation IGF-II expression. actions IGFs mediated interaction type 1 IGF cell surface receptor, which, like IGFs, is tissues. biologic effects modulated...
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