Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 2. Behavioral and cognitive changes.
作者： Roxanne Sterniczuk , Michael C. Antle , Frank M. LaFerla , Richard H. Dyck
DOI: 10.1016/J.BRAINRES.2010.06.011
关键词:
摘要: Alzheimer's disease (AD) is characterized by distinct behavioral and cognitive deficits that differ from those observed in normal aging. Transgenic models of AD are a promising tool understanding the underlying mechanisms cause disease. The triple-transgenic mouse model (3xTg-AD) only to exhibit both Abeta tau pathology characteristic human form. present study performance 3xTg-AD mice on several tasks measuring ability. Aged females exhibited higher level fear anxiety demonstrated increased restlessness, startle responses, freezing behaviors. No differences were muscle strength visuo-motor coordination. Understanding manifestations occur this may aid early diagnosis appropriate treatment symptomology.
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