Pressure Gradients in Solid Tumors
作者： Shawn Stapleton , Michael F. Milosevic
DOI: 10.1007/978-1-4614-7876-8_9
关键词:
摘要: In order to reach target cells, nanoparticles must transport through the systemic circulation, extravasate from blood vessels, and penetrate interstitial tissue. These processes occur by a combination of convection diffusion. Tissue pressure gradients play an integral role in directly indirectly mediating convective diffusive solid tumors. Specifically, poorly regulated tissue reduce micro-regional delivery, extravasation, penetration nanoparticles. this chapter we discuss pathogenesis abnormal tumors, describe their influence on enhanced permeability retention (EPR) effect, nanoparticle drug review methods modulate improve
springer.com
sci-hub.st 参考文章(182)
Suzie H Pun, Thomas T Goodman, Peggy L Olive, Increased nanoparticle penetration in collagenase-treated multicellular spheroids. International Journal of Nanomedicine. ,vol. 2, pp. 265- 274 ,(2007)
Ralph E. Durand, Intermittent blood flow in solid tumours--an under-appreciated source of 'drug resistance'. Cancer and Metastasis Reviews. ,vol. 20, pp. 57- 61 ,(2001) , 10.1023/A:1013181107707
E.C. Krishnan, L. Krishnan, W.R. Jewell, B. Jewell, P. Bhatia, Dose-dependent radiation effect on microvasculature and repair. Journal of the National Cancer Institute. ,vol. 79, pp. 1321- ,(1987)
The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies Springer Berlin Heidelberg. ,(2009) , 10.1007/978-3-540-74386-6
Mats Sjöquist, Carl-Henrik Heldin, Kristofer Rubin, Arne Ostman, Tobias Sjöblom, Elisabeth Buchdunger, Kristian Pietras, Inhibition of PDGF Receptor Signaling in Tumor Stroma Enhances Antitumor Effect of Chemotherapy Cancer Research. ,vol. 62, pp. 5476- 5484 ,(2002)
Laurence T. Baxter, Rakesh K. Jain, Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism. Microvascular Research. ,vol. 41, pp. 5- 23 ,(1991) , 10.1016/0026-2862(91)90003-T
Darell D. Bigner, Michael R. Zalutsky, Darrell A. Cope, Mark W. Dewhirst, Henry S. Friedman, Enhanced delivery of a monoclonal antibody F(ab')2 fragment to subcutaneous human glioma xenografts using local hyperthermia. Cancer Research. ,vol. 50, pp. 1803- 1809 ,(1990)
James Wei, Pietro M. Gullino, Edward A. Swabb, Diffusion and Convection in Normal and Neoplastic Tissues Cancer Research. ,vol. 34, pp. 2814- 2822 ,(1974)
Herman D. Suit, Genevièeve Griffon-Etienne, Christian Brekken, Yves Boucher, Rakesh K. Jain, Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications. Cancer Research. ,vol. 59, pp. 3776- 3782 ,(1999)
Einar K. Rofstad, Jon-Vidar Gaustad, Kjetil G. Brurberg, Berit Mathiesen, Kanthi Galappathi, Trude G. Simonsen, Radiocurability Is Associated with Interstitial Fluid Pressure in Human Tumor Xenografts Neoplasia. ,vol. 11, pp. 1243- 1251 ,(2009) , 10.1593/NEO.91152