Cerebral microangiopathy in patients with non-insulin-dependent diabetes mellitus.

摘要: Introduction: The aim of the study was to evaluate cerebral microangiopathy in type 2 non- insulin-dependent diabetes mellitus (NIDDM) patients and establish potentially conducive factors. Materials Methods: A group 34 with NIDDM 31 gender- age- matched normal controls (NC) were assessed by extracranial Doppler ultrasound, order pulsatility index (PI) resistance (RI) internal carotid arteries (ICAs); transcranial utilised assess same parameters middle (MCAs). All underwent screening for favouring factors vascular remodelling. Results: Of patients, 21 (61.76%) (subgroup A) presented microangiopathic complications (of these, 19 (90.46%) had diabetic nephropathy (DN)) versus 13 (38.24%) B) without complications. In subgroup A, 16 (76.19%) PI >1 RI >0.7 ICAs MCAs (changes consistent microangiopathy) 5 (35.46%) B, no modifications NC. DN, 14 (73.68 %) impaired haemodynamic indices. Univariate regression analysis showed following risk haemodynamics changes: fibrinogen (F) (OR = 3.11), C-reactive protein (CRP) 2.40), duration DM proteinuria 1.80), serum creatinine 1.66). Multivariate as predictors indices: (HR =1.70), 1.70). indices correlated (r 0.87, P <0.0001), F 0.86; CRP 0.80; <0.0001); 0.66, 0.38; 0.88; <0.0001). Conclusion: Cerebral has a high prevalence patients. These changes correlate DM, inflammation, proteinuria. Ann Acad Med Singapore 2007;36:259-66