Heterogeneity and Bipotency of Astroglial-Like Cerebellar Progenitors along the Interneuron and Glial Lineages

摘要: Cerebellar GABAergic interneurons in mouse comprise multiple subsets of morphologically and neurochemically distinct phenotypes located at strategic nodes cerebellar local circuits. These cells are produced by common progenitors deriving from the ventricular epithelium during embryogenesis prospective white matter (PWM) postnatal development. However, it is not clear whether these also shared other lineages germinative sites different PWM originate inhibitory interneurons. Indeed, cerebellum hosts another germinal site along Purkinje cell layer (PCL), which Bergmann glia generated up to first weeks, was proposed be neurogenic. Both PCL precursors displaying traits juvenile astroglia neural stem markers. First, we examine proliferative fate potential niches, showing that dynamics regulate progenitor amplification sites. In addition, differ progeny. exclusively astroglial-like progenitors, whereas produce only astrocytes. Finally, through vitro, ex vivo, vivo clonal analyses provide evidence a bipotent gives rise both