Recent developments in cholera.

摘要: Cholera continues to be an important public health problem among many poorer communities in Africa, Asia and South America, despite the bacteriology epidemiology of disease having been described over a century ago. Molecular techniques have enabled current researchers gain new insights into pathogenicity, relationships between environmental clinical strains, strategies for vaccine development. The description non-culturable 'dormant' strains environment effect factors on toxin gene regulation provide valuable clues ecology disease. Disease management based urgent appropriate rehydration, recent community studies emphasize need effective local services this if case fatality rates are remain low. While antimicrobial agents may play role prophylaxis, increasing prevalence resistance must addressed. New candidates, molecular understanding scope improved prevention, though context their use has not determined. This review summarizes activities these fields cholera research considers continuing global