Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons
作者： F. Balordi , G. Fishell
DOI: 10.1523/JNEUROSCI.1040-07.2007
关键词:
摘要: We examined the postnatal consequences of removing Hedgehog signaling within adult stem cell niche. Although at birth subventricular zone appears normal in mice lacking signaling, by day 8 it is greatly impaired, and death increased. In addition, both quiescent B population transit-amplifying C cells become depleted postnatally. contrast, A expands precociously, mostly fails to migrate olfactory bulbs, ultimately also 30. vitro vivo analyses demonstrate that this failure migration a result nonautonomous possibly caused reduction Slit1 ligand cells. These results suggest required for maintenance populations indirectly neurons are generated from
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