NRAS and KRAS polymorphisms are not associated with hepatoblastoma susceptibility in Chinese children

摘要: Hepatoblastoma is the most common hepatic malignancy in children, accounting for approximately 80% of all childhood liver tumors. KRAS and NRAS, members RAS gene family, are closely linked to tumorigenesis, frequently mutated a variety malignancies. They may thus play critical roles tumorigenesis. However, there few studies on association between polymorphisms risk hepatoblastoma. We investigated whether at these genes associated with hepatoblastoma susceptibility hospital-based study 213 affected Chinese children 958 cancer-free controls. Genotypes were determined by TaqMan assay, was assessed based odds ratios 95% confidence intervals. No significant differences observed patients controls terms age gender frequency. All NRAS genotypes Hardy–Weinberg equilibrium entire population. did not observe any KRAS. The selected after stratification age, gender, clinical stage. no even data suggest that irrelevant among