Preparation and characterization of glycoprotein-resistant starch complex as a coating material for oral bioadhesive microparticles for colon-targeted polypeptide delivery
作者： Wenbei Situ , Xiaoxi Li , Jia Liu , Ling Chen
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摘要: For effective oral delivery of polypeptide or protein and enhancement their bioavailability, a new resistant starch-glycoprotein complex bioadhesive carrier an colon-targeted microparticle system were developed. A glycoprotein, concanavalin (Con A), was successfully conjugated to the molecules starch acetate (RSA), leading formation complex. This Con A-conjugated RSA film as coating material showed excellent controlled-release property. In streptozotocin (STZ)-induced type II diabetic rats, insulin-loaded microparticles coated with this exhibited good hypoglycemic response for keeping plasma glucose level within normal range totally 44-52 h after administration different insulin dosages. Oral tolerance tests indicated that successive these at 50 IU/kg could achieve effect similar by injection 35 IU/kg. Therefore, potential film-coated has been demonstrated be capable improving bioavailability bioactive proteins peptides.
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