mTOR and cancer: insights into a complex relationship.
作者： David M. Sabatini
DOI: 10.1038/NRC1974
关键词:
摘要: … mTORC1 and mTORC2 complexes mTOR has key roles in several pathways that are involved in human cancer, stimulating interest in mTOR … drugs that target mTOR, the unexpectedly …
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M.W. Albers, R.T. Williams, E.J. Brown, A Tanaka, F.L. Hall, S.L. Schreiber, FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line. Journal of Biological Chemistry. ,vol. 268, pp. 22825- 22829 ,(1993) , 10.1016/S0021-9258(18)41602-X
André Marette, Frédéric Tremblay, Amino Acid and Insulin Signaling via the mTOR/p70 S6 Kinase Pathway A NEGATIVE FEEDBACK MECHANISM LEADING TO INSULIN RESISTANCE IN SKELETAL MUSCLE CELLS Journal of Biological Chemistry. ,vol. 276, pp. 38052- 38060 ,(2001) , 10.1074/JBC.M106703200
Richard F. Lamb, Christian Roy, Tom J. Diefenbach, Harry V. Vinters, Michael W. Johnson, Daniel G. Jay, Alan Hall, The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho. Nature Cell Biology. ,vol. 2, pp. 281- 287 ,(2000) , 10.1038/35010550
Richard C. Hresko, Mike Mueckler, mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes Journal of Biological Chemistry. ,vol. 280, pp. 40406- 40416 ,(2005) , 10.1074/JBC.M508361200
Xinsheng Gao, Yong Zhang, Peter Arrazola, Okio Hino, Toshiyuki Kobayashi, Raymond S. Yeung, Binggeng Ru, Duojia Pan, Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nature Cell Biology. ,vol. 4, pp. 699- 704 ,(2002) , 10.1038/NCB847
Michael E Williams, John J Densmore, Biology and therapy of mantle cell lymphoma. Current Opinion in Oncology. ,vol. 17, pp. 425- 431 ,(2005) , 10.1097/01.CCO.0000174039.69656.2B
Sohail F Tavazoie, Veronica A Alvarez, Dennis A Ridenour, David J Kwiatkowski, Bernardo L Sabatini, Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2 Nature Neuroscience. ,vol. 8, pp. 1727- 1734 ,(2005) , 10.1038/NN1566
Magdalena Karbowniczek, Gavin P. Robertson, Elizabeth Petri Henske, Rheb Inhibits C-Raf Activity and B-Raf/C-Raf Heterodimerization Journal of Biological Chemistry. ,vol. 281, pp. 25447- 25456 ,(2006) , 10.1074/JBC.M605273200
Andrew R. Tee, Rana Anjum, John Blenis, Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin. Journal of Biological Chemistry. ,vol. 278, pp. 37288- 37296 ,(2003) , 10.1074/JBC.M303257200
Laura G. Pedraza, Tian Xu, Christopher J. Potter, Akt regulates growth by directly phosphorylating Tsc2. Nature Cell Biology. ,vol. 4, pp. 658- 665 ,(2002) , 10.1038/NCB840